Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase. Prikaži več TPX2 has been reported to have two NLS-containing domains that mediate its localization to microtubules; one in the amino-terminal domain, and the other in the carboxy-terminal domain. In addition to an NLS, the … Prikaži več TPX2 has been shown in several biochemical assays to behave as a microtubule-associated protein (MAP) and co-localize with spindle microtubules during M-phase. It plays a role in microtubule nucleation and is regulated by importin Prikaži več When bound to microtubules, TPX2 recruits a plus-end directed motor protein, Xlp2, a protein that is required in early mitosis and localizes to spindle poles, to microtubule minus … Prikaži več Monitoring TPX2 gene mRNA expression during cell cycle progression in synchronized HeLa cells revealed that TPX2 expression is high in G2/M phase, decreases dramatically upon G1 phase entry, increases upon entry into S phase, and peaks again at … Prikaži več TPX2 recruits and activates Aurora A kinase by utilizing its short 43 amino acid long amino-terminal sequence to bind the catalytic domain of Aurora A, locking the kinase into its … Prikaži več When four-fold TPX2 over the endogenous level was injected into a blastomere with a two-cell embryo, cleavage arrest was induced. This arrest has been attributed to the amino acids 471-715 of the carboxy-terminus of the TPX2 protein, with the last 35 amino acids … Prikaži več When the cell is in interphase, because of its ability to bind to importin α and β, TPX2 has been found localized in the nucleus. This has been … Prikaži več Splet28. jun. 2024 · Amazon FBA で出品者の在庫も保管されています. アマゾンのフルフィルメントセンターでは、アマゾンが提供する出品者向けサービス、フルフィルメン …
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SpletSeveral TPX2-family proteins contain the N-terminal Aurora-binding domain and the central TPX2/Importinbinding domain, but lack TPX2-C (Tomastikova et al., 2015 (Tomastikova et al., , 2024 Boruc ... SpletFBA入庫係 芝生町1-52-2 高槻市, 大阪府 569-0823(1-52-2 Shibocho: ... TPX2: 松崎台2-4-3: SpletDepletion of TPX2 or its associated kinase Aurora-A preferentially reduced cell viability in a panel of BRCA2-de cient cancer cells. In line with these ndings, BRCA2-depleted and BRCA2-mutant ... brazilian steakhouse sioux falls