Gefitinib in lung cancer
WebThe T790M mutation is recognized as a typical mechanism of acquired resistance to first generation of epithermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib in non-small cell lung cancer (NSCLC) patients who are commonly treated by third generation of EGFR-TKI AZD9291 (osimertinib). WebStatistical analysis showed that patients with EGFR-positive lung cancer who received adjuvant TKIs tend to have a longer DFS compared with those who did not receive adjuvant gefitinib or erlotinib (HR =0.43, P =0.001).
Gefitinib in lung cancer
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WebOct 22, 2003 · Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer: A Randomized Trial Lung Cancer JAMA JAMA Network ContextMore persons in the United States die from non–small cell lung In preclinica [Skip to Navigation] WebSep 21, 2016 · Gefitinib (Iressa; AstraZeneca, Osaka, Japan) is an orally active, selective, tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) that binds to the adenosine triphosphate–binding pocket of the EGFR kinase domain and blocks downstream signaling pathways; gefitinib showed novel antitumor activity in patients …
WebIn the present study, we describe a case of treatment-naïve stage IIIB SqCLC that harbored a rare epidermal growth factor receptor (EGFR) p.E746_S752delinsV mutation with clinical complete response to neoadjuvant gefitinib. Pathological complete response was confirmed after surgical resection. No disease recurrence was documented after 20 ... WebFeb 1, 2024 · Importance: Use of tyrosine kinase inhibitors (TKIs) is the standard therapy for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) with brain metastases. Several studies have shown that adding chemotherapy to EGFR-TKIs could improve progression-free survival (PFS) in patients with EGFR-mutant advanced …
WebJul 4, 2012 · Lung cancer is the leading cause of cancer death in U.S. and represents a major public health burden. Epidemiologic data have suggested that lung cancer in women may possess different biological characteristics compared to men, as evidenced by a higher proportion of never-smokers among women with lung cancer. Emerging data indicate … WebAll patients were untreated with EGFR-TKIs and received first-line gefitinib (250 mg/day) or erlotinib (150 mg/day) and were then subsequently treated with other EGFR-TKIs (gefitinib, erlotinib, afatinib, or osimertinib). Treatments after the second-line treatment were determined by the treating physician.
WebNov 22, 2008 · INTEREST established non-inferior survival of gefitinib compared with docetaxel, suggesting that gefitinib is a valid treatment for pretreated patients with advanced non-small-cell lung cancer. Publication types Clinical Trial, Phase III …
WebNov 2, 2024 · We examined whether gefitinib for 2 years as adjuvant therapy for completely resected, stage II-III, non–small-cell lung cancer harboring EGFR mutation would improve the patient outcome compared with cisplatin plus vinorelbine adjuvant therapy by conducting a phase III trial. Knowledge Generated trust and estate accounting softwareWebApr 12, 2024 · We previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumor, and cell proliferation, and that EHE … philippos business centerWebMay 26, 2015 · Article: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, erlotinib or afatinib, are standard of care as first-line treatment for advanced non-small cell lung cancer (NSCLC) harbouring EGFR-activating mutations. 1 Adverse events associated with gefitinib are well known and include rash, pruritus, … philippos andreouWebIntroduction. Advanced non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. 1 The epidermal growth factor receptor (EGFR) tyrosine kinase … philip port rowland heightsphilippos-michalisWebSep 20, 2013 · Purpose: Survival of patients with completely resected non-small-cell lung cancer (NSCLC) is unsatisfactory, and in 2002, the benefit of adjuvant chemotherapy … philippos car serviceWebIntroduction. Lung cancer is the most common cancer and the most common cause of cancer death in males, while it is a fourth most commonly diagnosed cancer and the … philippos clark