Cisplatin alkylating agent

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August undefined, 2024

Some of the substances require conversion into active substances in vivo (e.g., cyclophosphamide). Cyclophosphamide is one of the most potent immunosuppressive substances. In small dosages, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemia, granulomatosis with polyangiitis, and other autoimmune diseases. High dosages cause pancytop… WebDec 19, 2011 · Alkylating agents Cause DNA cross-links and prevent cell replication ... The platinum-based chemotherapy agents cisplatin, carboplatin, and oxaliplatin, used to treat a huge number of cancers including the lung, upper and lower GI, ovarian, and germ cell tumours, are a common cause of renal tubular and glomerular damage, which can be …

Cisplatin - an overview ScienceDirect Topics

Webthe agent leaks outside the vein.15,17 A vesicant (Box 1) is any drug that has the potential to cause tissue damage when leakage occurs outside the vein.13 Box 1 Examples of … Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… tsx globe mail

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WebJun 13, 2005 · Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability … WebThe term “alkylating agent” has been defined and a detailed discussion made of the mechanisms (Sn1 and Sn2) by which they interact with nucleophilic centers. The various … Webthe agent leaks outside the vein.15,17 A vesicant (Box 1) is any drug that has the potential to cause tissue damage when leakage occurs outside the vein.13 Box 1 Examples of Vesicant Chemotherapy Agents Alkylating agents: DNA binding • Nitrogen mustard Anthracyclines: DNA binding • Daunorubicin • Doxorubicin • Epirubicin • Idarubicin pho delivery 78748

Chemotherapy Agents That Cause Cardiotoxicity - U.S. Pharmacist

Paclitaxel, cisplatin, and cyclophosphamide in human ovarian …

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebPlatinum compounds. The platinum compounds are largely used in the treatment of lung, breast, ovarian, and colon cancers. The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. If the DNA damage exceeds the ability of the cell to repair, the cell undergoes apoptotic cell death. tsx gWebThe term “alkylating agent” has been defined and a detailed discussion made of the mechanisms (Sn1 and Sn2) by which they interact with nucleophilic centers. The various nucleophiles likely to be encountered in vivo are discussed in terms of their relative reactivities toward alkylating agents. tsx gold index

"Web24 minutes ago · Ovarian cancer that began in the epithelial layer protecting the ovary is known as epithelial ovarian cancer. The different types of drugs include alkylating agents, mitotic inhibitors ... " - Cisplatin alkylating agent

Cisplatin alkylating agent

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebMar 10, 2015 · The alkylating agents are generally separated into six classes: (1) The nitrogen mustards [mechlorethamine, cyclophosphamide, ifosfamide, melphalan and chlorambucil] 2. Ethylenamine and … WebAlkylating agents Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell cycle and are used to treat many different cancers, including cancers of the lung, breast, and ovary as well as leukemia, lymphoma, Hodgkin disease, multiple myeloma, and sarcoma.

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WebMMR-deficient cells have been reported to be resistant to the methylating agents procarbazine and temozolomide, the alkylating agent busulfan, the platinum-containing drugs cisplatin and carboplatin, the antimetabolite 6-thioguanine, and the topoisomerase II inhibitors etoposide and doxorubicin. WebCytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity.

WebThe three most active types of agents in the treatment of cancer of the ovary are platinum compounds (cisplatin or carboplatin), bifunctional alkylating agents … WebNitrosoureas are a particular type of alkylating agent. Unlike other alkylating agents, nitrosoureas can travel into your brain and kill cancer cells there. Nitrosoureas are used to treat some brain tumors. Selected alkylating agents include: Altretamine. Bendamustine. Busulfan. Carboplatin. Chlorambucil. Cisplatin. Cyclophosphamide ...

WebMar 26, 2024 · For platinum alkylating-like drugs, in contrast to the parent compound cisplatin, the newer-generation drug carboplatin is reported to have reduced toxicity in …

WebAlkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. There are several types of alkylating agents: Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. Ethylenimines: Thiotepa and Hexamethylmelamine. Alkylsulfonates: Busulfan. pho delivery 80033Web第七章抗肿瘤药.pptx,Chapter 13 Antineoplastic Agents;Classification by mechanism; 13.1 Biological alkylating agents; Bioalkylating agents are cytotoxic drugs. In vivo, it is able to form a positive charged carbon-ion or other active electrophilic groups, and then the el tsx gmg pricesWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … pho delivery 92101WebCisplatin is similar to the bifunctional alkylating agents. It covalently binds to DNA and disrupts DNA function. 6. After cisplatin enters the cells, the chloride ligands are … pho delivery 80233WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … tsx global gold indexWeb26 minutes ago · This report provides strategists, marketers and senior management with the critical information they need to assess the market. The global ovarian cancer drugs market will grow from $3.20 billion ... pho delivery 90046WebAlkylating agents (AAs), are a group of chemo drugs generally divided into six classes; triazenes, nitrogen mustards, nitrosoureas, ethylenimine and methylenamine derivatives, alkyl sulfonates, and platinum-containing antineoplastic agents, which are commonly used, alone or in combination, in high-dose chemotherapy regimens to treat certain types of … tsx graph 2018